Effect of ursodeoxycholic acid (UDCA) on primary biliary cirrhosis.
نویسندگان
چکیده
منابع مشابه
Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis.
This placebo-controlled, randomized, multicenter trial compared the effects of MTX plus UDCA to UDCA alone on the course of primary biliary cirrhosis (PBC). Two hundred and sixty five AMA positive patients without ascites, variceal bleeding, or encephalopathy; a serum bilirubin less than 3 mg/dL; serum albumin 3 g/dL or greater, who had taken UDCA 15 mg/kg daily for at least 6 months, were stra...
متن کامل[Treatment of primary biliary cirrhosis with ursodeoxycholic acid].
This study was undertaken to evaluate the efficacy of ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis (PBC). Three patients with PBC (stage II) have been treated with UDCA (Ursofalk and Falk Pharma, Freiburg, Germany)--of 10 mg/kg daily dosage in the course of three years. Patients with well-defined PBC underwent complete history, physical examination, liver chemistrie...
متن کاملCost-effectiveness of ursodeoxycholic acid therapy in primary biliary cirrhosis.
Ursodeoxycholic acid (UDCA) is a safe and effective treatment for patients with primary biliary cirrhosis (PBC), but the cost of this drug has raised concerns regarding cost-effectiveness. The aim of our study was to determine the cost-effectiveness of UDCA in PBC. We compared the costs and outcomes of managing PBC patients with and without UDCA. From two previously published trials, the effect...
متن کاملThe ursodeoxycholic acid story in primary biliary cirrhosis.
The ursodeoxycholic acid story in primary biliary cirrhosis The name ursodeoxycholic acid (UDCA) is derived from 'ursocholeinische saure' used by Hammarsten in 1902 to describe a bile acid discovered in polar bears. The bile acid he identified was actually chenodeoxycholic acid.1 UDCA is the 7P epimer of chenodeoxycholic acid and has the chemical structure 3a 7,B-dihydroxy-5p-cholan-24-oic acid...
متن کاملUrsodeoxycholic Acid (UDCA) in Biliary Diseases: A Clinical Review
Ursodeoxycholic acid (UDCA) is an established and accepted treatment of biliary diseases such as gallstones and primary biliary cirrhosis. Mechanisms of action of UDCA are not so far completely elucidated. UDCA tablets are indicated for the dissolution of small to medium sized radiolucent, cholesterol-rich gall-stones in patients with a functioning gall bladderand in the treatment of primary bi...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1990
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.21.87